279

interaction partners. Numerous RNA interaction partners can also be predicted bioinfor­

matically, for example with miRanda or TargetScan. It is important to note that these pre­

diction algorithms are based on different parameters, such as prediction by seed region

and/or folding energy, and often find too many potential interaction partners and have a

high false positive rate. For a basic introduction and further information, we recommend

our two review articles (https://www.ncbi.nlm.nih.gov/pubmed/25486579; https://www.

ncbi.nlm.nih.gov/pubmed/28035947), which introduce numerous databases and programs

for the functional analysis of miRNAs and lncRNAs and discuss problems in the analysis.

For practice, one can take a look at our analysis pipeline (https://academic.oup.com/bib/

article/21/4/1391/5553031).

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19.14

19.2  RNA: Sequence, Structure Analysis and Control of Gene Expression